Aleve When you're tired of taking and retaking pills every few hours to deal with long-lasting aches and pains, Aleve can help. Just 1 caplet is strong enough to provide pain relief that can last up to 12 hours, which means no more stopping throughout the day to take more caplets. For relief of minor aches and pains due to minor pain of arthritis, muscular aches, backache, menstrual cramps, headache, toothache and the common cold.